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1996-03-09
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Document 0171
DOCN M9650171
TI Kaposi's sarcoma in childhood: an analysis of 100 cases from Uganda and
relationship to HIV infection.
DT 9605
AU Ziegler JL; Katongole-Mbidde E; Uganda Cancer Institute, Kampala,
Uganda.
SO Int J Cancer. 1996 Jan 17;65(2):200-3. Unique Identifier : AIDSLINE
MED/96152770
AB We report 100 cases of Kaposi's sarcoma (KS) in children under 15 years
of age treated at the Uganda Cancer Institute in the 6-year period
1989-1994. The incidence of childhood KS has risen more than 40-fold in
the era of AIDS, and 78% of 63 cases tested were seropositive for HIV-1.
There were 63 boys and 37 girls. The median age was 4 years and the
median age of onset was 33 months. Tumour distribution was
lymphadenopathic and muco-cutaneous, with 2 major patterns: pattern I,
oro-facial dominant (79%); and pattern II, inguinal-genital dominant
(13%). A newly described herpes-like virus is implicated as the cause of
KS (KSHV), and DNA sequences of this virus were present in all of 8
childhood cases tested. If KSHV is a direct cause of KS, this tumour
distribution in children suggests mucosal routes of virus entry,
possibly during birth or breast feeding. The dramatic increase of
childhood KS implies that the prevalence of causative factors is rising
in Uganda.
DE Age Factors Child, Preschool Female Human HIV
Infections/*COMPLICATIONS Infant Infant, Newborn Male Prevalence
Sarcoma, Kaposi's/EPIDEMIOLOGY/*ETIOLOGY/PHYSIOPATHOLOGY Sex Factors
Support, Non-U.S. Gov't Uganda/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).